Session 1.1.2

CHEMICAL APPROACHES TO EXPANDING THE GENETIC CODE

Keywords

Expanded genetic code, modified nucleic acids, unnatural amino acids, artificial enzymes, modified proteins, orthogonal ribosome, therapeutic oligonucleotides, Darwinian in vitro evolution.

Speakers

  • KN: Jason CHIN (MRC, University of Cambridge, UK)

  • IL1: Piet HERDEWYN (KU Leuven, BE)

  • IL2: Philipp HOLLIGER (MRC, University of Cambridge, UK)

 

Abstract

Expansion of the genetic code beyond the 20 natural amino acids and the 2 base pair system of DNA is a long-standing goal in synthetic biology. Applications are manifold and include site-selective labeling of biopolymers, development of semi-synthetic organisms, and generation of novel nano and biomaterials. Chemistry plays a central role in the development of this field which will be highlighted in this session.